devil room pool, devil deal, paper, pink, brown, isaac, Gives a 50% chance to not take damage from projectiles, * golden chest pool, gold chest pool, secret room pool, item room, treasure room, item room pool, The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. Re-rolled items pick from the current room's item pool, Isaac starts with this item after it is unlocked, UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby, * item room, treasure room, item room pool, dice pip, starting, pink, red, cube, Bombs now do 185 damage (up from 100) and have a larger blast radius, Has a chance to drop from the Super Wrath miniboss fight, REPENTANCE - Mr. Mega bombs buffed from 110 to 185 each, UNLOCK: Unlock this item by destroying 10 tinted rocks, Item Pool: Item Room, Bomb Beggar, Super Wrath Miniboss, * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, slackaholicus, grey, gray, face, Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick, * item room, treasure room, item room pool, scissors, cutters, snip, scissors, silver, grey, gray, All damage taken is reduced to half a heart, Damaged reduction is reduced from every source in the game except Devil Deals and health down pills, Does not prevent death (i.e. in shops or devil rooms), The only way to survive the falling sword is either through extra lives, by using items that would make you invincible, such as Gnawed Leaf or playing as The Lost. You get a couple of seconds of invincibility to move away after, The main benefit of this Soul Stone is that it automatically activates if you die, meaning it is effectively an extra passive life while held, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lazarus, Activates the D6 and D20 effects, rerolling all items and pickups in the room. Be warned though, Mom's leg can also stomp and hurt Isaac too! Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. They also no longer block player attacks or get extinguished by them, UNLOCK: Unlock this item by donating 400 pennies to the Shop, Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar, Soul hearts and black hearts cannot be stored, If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart, * shop room pool, shop item pool, the lost item pool, glass. There's Options, Double item room, Boss Rush) the Moving Box will pick only one of the items at random, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by HurleyFarrill, UNLOCK: Unlock this item by using Pandora's Box in the Dark Room floor, Your tears will now be connected together by beams of electricity which deals damage to enemies they hit, The lasers from this item deal 30% of your current damage stat, REPENTANCE - Technology Zero's lasers now deal 30% of the player's damage stat per tick (from 100%), UNLOCK: Unlock this item by having 2 technology items at once, *, black, white, grey, gray, round, circle, eye, key, hole, coin, slot, laser, Taking damage will spawn an orbital that rotates around Isaac, dealing contact damage to enemies and blocking enemy projectiles, A maximum of 3 Leprocy orbitals can be active at one time, Using the orbital to deal damage to enemies can cause it to break, Added as part of the Afterbirth+ Booster Pack #2. Pressing 3 yellow buttons on the floor causes the minecart to be rideable. starting, bloody, white, bandages, lazarus rags, Gives Isaac a full mapping effect, revealing the entire floor and locations of all secret rooms, UNLOCK: Unlock this item by beating Satan with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. Gives a one-time use of the D6 and D20 effects at the same time, When used will cause two of Mom's Hand to come down and grab a random enemy, Grants the Holy Mantle effect for, which will negate your next hit of damage, Tainted Lost starts with this card, and while playing as this character all cards and runes have a 10% chance to turn into a Holy Card, UNLOCK: Unlock this item by defeating Delirium in The Void floor with The Lost. purple, pink, mask, face, Puts a shield in front of Isaac which blocks projectiles, The shield will rotate based on the direction in which Isaac is firing tears, * angel room pool, god room pool, angel room item, blue, silver, metal, Gives Isaac a laser that will fire at random intervals in addition to your normal tears, Each laser does damage equal to your current tear damage, The laser will occasionally fire with one of these effects: Hook Worm, Spoon Bender, Tiny Planet, Mysterious Liquid, Rubber Cement, Luck has no effect on the rate at which Tech.5 fires and does not scale with items that increase your tears stat, UNLOCK: Unlock this item by beating Challenge #18 (The Host), * technology.5, tech 5, item room, treasure room, item room pool, white, red, eye, robot, Isaac now shoots two tears at once, but dealing -20% damage each, Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, * 20 20, 2020, item room, treasure room, item room pool, black glasses, spectacles, Reveals the locations of the secret and super secret room for the current floor and all future floors, UNLOCK: Unlock this item by donating 10 pennies to the Shop, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, All your items and consumables are temporarily removed while in the abandoned mine, The room to access Knife Piece 2 only appears if you have Knife Piece 1 already, You can skip pressing the 3 yellow buttons if you have the ability to fly and have 2 bombs to force open the door, When combined with Knife Piece 1, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, This is a one time use item that teleports you to an alternate floor, which contains every single item in the game, The items are spread between several different rooms all on pedestals. ?, Satan and The Lamb as Tainted Eve, A small clot friend will hug Isaac, following his exact movements (similar to how Jacob & Esau work) and shooting tears when he does, The clot can be moved around by collision with an object/wall, allowing you to re-position it, The clot's damage is roughly 1/3 of your tear damage, If it takes a few hits it will die, and respawn in the next room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eve, Spawns a random chest after completing a regular Challenge Room, Spawns a pedestal item after completing a boss Challenge Room, UNLOCK: Unlock this trinket by defeating Isaac, ?? You can also try doing this in Big Picture Mode. The size resets when leaving the floor, UNLOCK: Unlock this item by defeating The Beast as Tainted Lazarus, A fetus familiar follows Isaac, and upon entering the Boss room on each floor, it will transform into a copy of the boss, This makes bosses a lot harder, however you now get 2 boss item drops, UNLOCK: Unlock this item by defeating Hush as Jacob & Esau, You gain two familiar demons, that stay by Isaac's side and fire shots in the same direction as you, The familiars deal roughly 40% of Isaac's damage, scaling with damage upgrades you get, They sit near and rotate around Isaac depending on which way you're firing tears. When an enemy takes damage from an enemy projectile, it will attempt to target the enemy that fired it, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Judas, Item Pool: Item Room, Greed Mode Item Room, Devil Room, Greed Mode Devil Room, Zodiac will give you a random zodiac item effect that changes after every floor, Possible item effects include: Taurus, Aries, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius, Gemini or Pisces, UNLOCK: Unlock this item by beating Greed Mode with The Lost, Tears now have a random chance to apply a poison effect, dealing damage equal to your tears each tick, for 2 ticks, Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick), Enemies that were poisoned by contact damage have a 20% chance to drop a black sin heart when killed. * devil pool, devil room pool, devil deal, the lost item pool, cross, upside down, red, black. the ability to fly. Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Tears have a chance to become a tooth, dealing x3.2 damage, similar to Tough Love, The chance to fire a tooth with this trinket is affected by your Luck stat, At +0 luck you have ~12% chance for this effect to activate, At +9 luck every tear you fire will be a tooth, Chance to spawn half a soul heart when picking up a coin, The chance scales up based on the coin's worth: Penny = 16.66%, Double Penny = 30.5%, Nickel = 59.7%, Dime = 83.3%, UNLOCK: Unlock this trinket by defeating ??? The Binding of Isaac: Rebirth. You must make it back through the path solving a few bomb puzzles while avoiding her, to get back to the regular floor. Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. 23 days ago. Each secret room contains a beam of light, that gives half a soul heart, and a Tears Up for the rest of the floor. There are two different types of items; Active or Passive items. It also leaves a gas cloud at the place where it exploded, The bomb deals 185 damage + your tear damage on hit and leaves a damage over time poison effect that does 3 times your tear damage per tick, Synergizes with tear modifying items such as My Reflection or Tiny Planet, Has a chance to drop from the Sloth miniboss fight, Counts as 1 of 3 poison items needed towards the Bob transformation, REPENTANCE - The damage of this item was significantly boosted to 185 (from 50) in Repentance, and given the poison cloud effect. Displays additional information like item type, charges, transformations, Spindown Dice results, Bag of Crafting recipes, TMTRAINER item effects (Detailed informations require --luadebug flag! pill if no other pills were used yet. It's a 20% chance on first miss, 33% for a second miss and 50% for anything beyond that, Piercing shots work with this item and multiple hits with a single tear will each give a damage bonus, *, bullseye, target, grey, gray, black, red, circle, Isaac has a random chance to fire a Holy tear, which when it hits an enemy, will spawn a light beam on the same enemy, dealing damage, The beams from this item deal damage equal to 400% of your tear damage (4x damage multiplier for the beams only), The chance to fire a Holy tear is affected by your luck stat, maxing out at a 50% chance, Item Pool: Item Room, Greed Mode Item Room, Angel Room, A familiar host that sits on Isaac's head and has a 20% chance to block enemy shots, When a shot is blocked, Host Hat will fire 3 bullets back at the enemy, Causes you to become immune to explosions, but doesn't protect against stomps or shockwaves, Causes your shops to instantly restock their items when you buy them, New items generated by Restock are from the shop item pool, The cost increases exponentially every time you purchase an item. The item order is based on the original The Binding of Isaac up to item 129 ( A Lump of Coal ), and its expansion, Wrath of the Lamb, up to item 195 ( Box ). Confuses all enemies briefly when destroyed, White poop - Same effect as Hallowed Ground, Stone poop - Deals extra thrown damage, can hit multiple enemies. You still take damage however when using Blood Donation machines and Devil Beggars, *, spikes, spikey, spike rock, greyhost, grey host, Causes all pedestal items to show up as rotating items, that swap every 1 second between the original spawned item and a HP up item. 3,245. as Jacob & Esau, This item has a different effect for each character. Build-defining, game-winning items that will likely carry any run that gets them. Throwing this at the Great Gideon boss will trigger a special animation and reveal a crawl space containing several chests and items! *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game.